Harvard Medical School uses PolyPico technology to support research into Chemotaxis and swarming in differentiated Human leukemia cell line (HL60) neutrophil-like cells.
PolyPico Technologies is proud to support cutting-edge biomedical research at Harvard Medical School, where its ultra-precise microdispensing system is being used in the study of chemotaxis and swarming behaviors in differentiated HL60 neutrophil-like cells, a human leukemia cell line.
Precision Dispensing for Complex Cell Behavior Studies
Neutrophils—an essential part of the immune system—navigate through tissues in response to chemical signals in a process called chemotaxis. Understanding how these cells move and coordinate their behavior in swarms is vital for developing treatments for infections, inflammatory conditions, and immune disorders.
At Harvard, researchers are using HL60 cells that have been chemically differentiated to exhibit neutrophil-like behavior. This cell model is ideal for observing immune responses under controlled laboratory conditions.
To explore how these cells react to chemotactic gradients, the research team turned to PolyPico’s micro drop dispensing technology, which allows them to deliver ultra-small volumes of chemoattractants with pinpoint accuracy**. This enables the creation of precise chemical gradients, essential for observing how neutrophil-like cells sense and respond to external cues in real time.
Why PolyPico?
PolyPico’s system dispenses picoliter- to nanoliter-scale droplets in a contactless and highly repeatable manner. These capabilities are crucial for studies requiring:
* High spatial resolution in chemical gradient formation
* Non-invasive droplet delivery to sensitive cell cultures
* Minimal reagent waste
* Controlled experimental reproducibility
This level of precision provides researchers at Harvard Medical School with the tools they need to model real-life immune responses and understand the dynamics of swarming—where neutrophil-like cells coordinate collective movement toward a threat, such as an infection.
Accelerating Immunological Discoveries
By combining advanced cell biology with high-precision microdispensing, the Harvard team is able to generate detailed insights into how immune cells behave, interact, and adapt. This research not only deepens our understanding of innate immunity but also paves the way for innovations in immunotherapy, infection control, and inflammatory disease treatment.
PolyPico is honored to see its technology contributing to such vital research. It’s a clear example of how high-precision tools can drive discovery in complex biological systems and support the development of next-generation medical solutions.
For other use cases, please refer to the following:
Antibiotic degradation by beta-lactamases deciphering last-resort
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